| Abstrak/Abstract |
Calcium plays an important role in normal hemostatic mechanisms. It was also known from the previous report that calcium signaling is a necessary component of the epidermal to migrate and response to wounding. In view of this, it was considered that hemostatic sponge containing a certain amount of calcium is important for wound healing management. In this study, results on the development, characterization, and in vivo animal experiments of carbonate apatite (CHA) enriched hemostatic sponges were presented. The CHA was successfully synthesized inside the gelatin networks, resulting in B-type carbonate ions substitution which allows dissolution and release of Ca2+ ions into the injured area, thus fastening wound healing and regeneration. The presence of CHA in 0.5 weight% which crosslinked for 48 hours was found to be superior to promote wound closure and regeneration when compared to commercially available porcine sponges. Based on the results of the study, it opens the horizon on the use of bio-ceramics in wound healing management. |
