| Abstrak/Abstract |
The application of bioceramic hydroxyapatite (HA) derived from materials high in calcium to tissue
engineering has been of concern, namely scaffold. Scaffold pores allow for cell mobility metabolic processes, and
delivery of oxygen and nutrients by blood vessel. Thus, pore architecture affects cell seeding efficiency, cell viability,
migration, morphology, cell proliferation, cell differentiation, angiogenesis, mechanical strength of scaffolds, and,
eventually, bone formation. Therefore, to improve the efficacy of bone regeneration, several important parameters
of the pore architecture of scaffolds must be carefully controlled, including pore size, geometry, orientation,
uniformity, interconnectivity, and porosity, which are interrelated and whose coordination affects the effectiveness
of bone tissue engineering. The honeycomb (HCB) as natural polymeric porogen is used to pore forming agent of
scaffolds. It is unique for fully interconnected and oriented pores of uniform size and high mechanical strength in
the direction of the pores. The aim of this study was therefore to evaluate the effect of HCB concentration on
macropore structure of the scaffolds. |
