Karya
Judul/Title Bioactivity of Fungi Trichoderma reesei Associated with Sponges Stylissa flabelliformis Collected from National Park West Bali, Indonesia
Penulis/Author Prof. Dr. apt. Erna Prawita Setyowati, M.Si. (1) ; Dr. Sylvia Utami Tunjung Pratiwi, S.Si., M.Si. (2); Prof. Dr.rer.nat. apt. Triana Hertiani, S.Si., M.Si. (3); Oka Samara (4)
Tanggal/Date 2017
Kata Kunci/Keyword
Abstrak/Abstract Objective: In this study, antimicrobial and cytotoxic properties of ethyl acetate extract of fermented Trichoderma reesei(T. reesei)fungi associated with the sponge Stylissa flabelliformis (S. flabelliformis) was tested. Materials and Methods: Fermentation of T. reeseiwas carried out in the saboroud dextrosa saline broth. The fermented filtrate was extracted using ethyl acetate. The ethyl acetateextract was tested for its antimicrobial and cytotoxic activity. Thin-layerchromatography and gas chromatography mass spectrometry were performed to determine the metabolite classes of compounds responsible for antimicrobial and cytotoxic activity. Results: Ethyl acetate extract of T. reesei was active against the bacteria Staphylococcus aureusATCC 29213, Eschericia coli ATCC 25922 and Candida albicansATCC 10231. The ethyl acetate extract was also active against cancer cells T47D and Raji cells, with IC50 values of 270 and 470 µg mLG 1 , respectively. Conclusion: An ethyl acetate extract of Trichoderma reeseif er ment at ions showed ant imicr obial and cyt ot oxic act ivit y. The compounds contained in the extract of T. reesei are terpenoids or phenyl propane derivatives.
Rumpun Ilmu Biologi Farmasi
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Bioactivity of Fungi Trichoderma reesei Associated with Sponges Stylissa flabelliformis Collected from National Park West Bali, Indonesia.pdf
2Bioactivity of Fungi Trichoderma reesei Associated with Sponges Stylissa flabelliformis Collected from National Park West Bali, Indonesia.pdf[PAK] Cek Similarity