BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS
Penulis/Author
Prof. Dr.rer.nat. apt. Raden Rara Endang Lukitaningsih, S.Si., M.Si. (1)
Tanggal/Date
2014
Kata Kunci/Keyword
Abstrak/Abstract
In Indonesia, the roots of bengkoang (Phacyrhizus erosus)
have been used as the excipient for sun screening and skin
whitening paste. Since the active compounds exhibiting skin
whitening or sun screening effect have not previously been
studied, the aim of this study was to identify compounds with
antioxidant and tyrosinase inhibitor activities. Soxhlet extraction
was used as the method of isolation with petroleum ether as the
solvent and it was followed by fractionation using ethyl acetate
to obtain three isoflavonoids (i.e. daidzein (2); daidzein-7-O-ß-
glucopyranose (3); 5-hydroxy-daidzein-7-O-ß-glucopyranose
(4)), and a new pterocarpan (i. e. 8,9-furanyl-pterocarpan-3-ol
(1)) which antioxidant activities (SC50% values) of 2.11; 11.86;
0.69 and 7.86 respectively. All compounds showed tyrosinase
inhibiting activities with IC50 values of 4.38; 5.35; 7.49 and
22.20 mM, respectively for compound 4, 2, 1 and 3. These
compounds can be used as antioxidant and skin whitening
materials
Rumpun Ilmu
Farmasi Umum dan Apoteker
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Naskah MFI 25(2) 2014.pdf
2
Bukti korespondensi MFI 25-2-Bioactive of Pachyrhizus erosus.pdf
