Fruits as the major source of nutrition have been investigated for their emerging evidence in bearing several neuroprotective activities beneficial to Alzheimer’s Disease (AD). This paper discusses recent evidence suggesting several fruit-derived bioactive substances that possess anti-AD activity. The original articles from 2011-2022 were collected from Pubmed and Scopus with related keywords and filtered. Several fruit constituents have shown a significant inhibitory action against β-amyloid and tau hyperphosphorylation either directly or indirectly via secretase inhibition. Some were also found to be cholinesterase inhibitors with specific antioxidative roles, disruptors of the neuroinflammation system, and promoters of neurogenesis and neurogenic process. Many fruit phytochemicals remarkably alter the capability defects shown in AD animal models such as catechin, nobiletin, and alpha-mangostin. Therefore, further investigations exploring a certain bioactive isolate or formulated dosage form and its mechanism of action are necessary to provide effective prevention and supplementary treatment for AD.
Rumpun Ilmu
Farmakologi dan Farmasi Klinik
Bahasa Asli/Original Language
English
Level
Nasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
acceptance letter 4491 281122 JPSC Yurida.pdf
Bukti Accepted
2
2022 - Annisa et al for JPSCR -similarity by Turnitin 12%.pdf
[PAK] Cek Similarity
3
4491 - manuscript.pdf
[PAK] Full Dokumen
4
Yurida et al BUKTI KORESPONDENSI ARTIKEL JPSC USD 2022.pdf
[PAK] Bukti Korespondensi Penulis
5
[PAK] Full dokumen Annisa et al___Yuniarti 2023 JFSK.pdf
[PAK] Full Dokumen
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[PAK] Cek similarity Annisa et al ___ Yuniarti 2023 JFSK.pdf
