Behavior of POP–Calcium Carbonate Hydrogel As Bone Substitute With Controlled Release Capability: A Study In Rat
Penulis/Author
Dr. drg. Anne Handrini Dewi, M.Kes. (1); Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (2); Joop Wolke (3); John Jansen (4)
Tanggal/Date
2015
Kata Kunci/Keyword
Abstrak/Abstract
Gypsum or Calcium Sulfate (CS) or Plaster of Paris (POP) is considered as a fast degradable material that usually resorps before the bone defect area is completely filled by new bone. In this study, the incorporation of CaCO3 hydrogel into POP in different compositions was proposed to enhance the bone biological activity of POP and to decrease its degradability. The mechanical and degradation properties of the various materials were characterized by in vitro analysis. Subsequently, the materials were inserted into cylindrically-sized bone defects as created into the femoral condyle of rats and left in situ for 1, 4 and 8 weeks. Histological analysis of the retrieved specimens indicated that the addition of CaCO3 hydrogel into POP increased bone formation, angiogenesis and collagen density and resulted into faster bone formation and maturation. It was also confirmed that the degradation rate of the POP decreased by the addition of CaCO3 hydrogel. The in vivo findings did corroborate with the in vitro analysis. In conclusion, the incorporation of CaCO3 hydrogel provides a promising technology to improve the properties of POP, the oldest biomaterial used for bone grafting.
Rumpun Ilmu
Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Behavior of POP–calcium carbonate hydrogel as bone substitute with.pdf
[PAK] Full Dokumen
2
Akreditasi Journal of Biomedical Materials Research Part A.pdf
3
11_ Similaritas Behavior of POP–calcium carbonate hydrogel as bone substitute with.pdf
