Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations
Penulis/Author
Prof. dr. Gunadi, Ph.D, Sp.BA., Subsp.DA(K) (1); dr. Mohamad Saifudin Hakim, M.Sc, Ph.D. (2); drh. Hendra Wibawa, M.Si., Ph.D. (3); MARCELLUS (4); dr. Ika Trisnawati, M.Sc., Sp.PD-KP (5); ENDAH SUPRIYATI (6); Afiahayati, S.Kom., M.Cs., Ph.D (7); dr. Riat El Khair, M.Sc., Sp.PK. (8); dr. Kristy Iskandar, M.Sc, Ph.D, Sp.A. Subsp.Neuro.(K) (9); dr. Siswanto, Sp.P(K) (10); Irene (11); dr. Nungki Anggorowati, Sp.PA(K)., Ph.D. (12); dr. Marselinus Edwin Widyanto Daniwijaya, Ph.D., Sp. MK (13); dr. Dwi Aris Agung Nugrahaningsih, M.Sc., Ph.D (14); YUNIKA PUSPA DEWI (15); Susan Simanjaya (16); RADEN AJENG DYAH AYU (17); HANA FAUZYYAH HANIFIN (18); ALVINA ALEXANDRA S (19); IRENE TANIA (20); CITA SHAFIRA AMALIA (21); I PUTU ADITIO ARTAYASA (22); HARIES RACHMAN (23); Herdiyanto Mulyawan (24); dr. Nur Rahmi Ananda, Sp.PD-KP. (25); Prof. dr. Eggi Arguni, M.Sc., Ph.D., Sp.A(K). (26); Prof. dr. Titik Nuryastuti, M.Si., Ph.D., Sp.MK(K). (27); Prof. dr. Tri Wibawa, Ph.D., Sp.MK(K) (28)
Tanggal/Date
1 2021
Kata Kunci/Keyword
Abstrak/Abstract
The outcome of SARS-CoV-2 infection is determined by multiple factors, including the viral, host genetics, age, and comorbidities. This study investigated the association between prognostic factors and disease outcomes of patients infected by SARS-CoV-2 with multiple S protein mutations. Fifty-one COVID-19 patients were recruited in this study. Whole-genome sequencing of 170 full-genomes of SARS-CoV-2 was conducted with the Illumina MiSeq sequencer. Most patients (47%) had mild symptoms of COVID-19 followed by moderate (19.6%), no symptoms (13.7%), severe (4%), and critical (2%). Mortality was found in 13.7% of the COVID-19 patients. There was a significant difference between the age of hospitalized patients (53.4 ± 18 years) and the age of non-hospitalized patients (34.6 ± 19) (p=0.001). The patients’ hospitalization was strongly associated with hypertension, diabetes, and anticoagulant and were strongly significant with the OR of 17 (95% CI=2-144; p=0.001), 4.47 (95% CI=1.07-18.58; p=0.039), and 27.97 (95% CI=1.54-507.13; p=0.02), respectively; while the patients’ mortality was significantly correlated with patients’ age, anticoagulant, steroid, and diabetes, with OR of 8.44 (95% CI=1.5-47.49; p=0.016), 46.8 (95% CI=4.63-472.77; p=0.001), 15.75 (95% CI=2-123.86; p=0.009), and 8.5 (95% CI=1.43-50.66; p=0.019), respectively. This study found the clade: L (2%), GH (84.3%), GR (11.7%), and O (2%). Besides the D614G mutation, we found L5F (18.8%), V213A (18.8%), and S689R (8.3%). No significant association between multiple S protein mutations and the patients’ hospitalization or mortality. Multivariate analysis revealed that hypertension and anticoagulant were the significant factors influencing the hospitalization and mortality of patients with COVID-19 with an OR of 17.06 (95% CI=2.02-144.36; p=0.009) and 46.8 (95% CI=4.63-472.77; p=0.001), respectively. Moreover, the multiple S protein mutations almost reached a strong association with patients’ hospitalization (p=0.07). We concluded that hypertension and anticoagulant therapy have a significant impact on COVID-19 outcomes. This study also suggests that multiple S protein mutations may impact the COVID-19 outcomes. This further emphasized the significance of monitoring SARS-CoV-2 variants through genomic surveillance, particularly those that may impact the COVID-19 outcomes.
Rumpun Ilmu
Ilmu Kedokteran Umum
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Form-L1-9th-ScientificReports_SARSCoV2.pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
2
Fulldoc_association between prognostic and outcome sars cov2.pdf
[PAK] Full Dokumen
3
Association between prognostic factors and the outcomes of patients infected with SARS?CoV?2 harboring multiple spike protein mutations.pdf
