| Abstrak/Abstract |
The aim of this study is to develop a polymeric drug delivery system for a nonsteroid anti inflammatory. Nanosuspensions of piroxicam were prepared by evaporative antisolvent precipitation methode (bottom-up technique) proved to be effective in improving the oral bioavailability as a result of enhanced solubility and bioavailability. To achieve this objective, the formulations were prepared by using experimental design (Simplex Lattice) to study the effects of formulation, variables as Chitosan (X1), Polivinylpirolidon PVP K30 (X2) and Sodium Tripoliposphat STPP (X3) in combination or singly on response of particle size (Zav), polidispersity index (DPI), zeta potensial (ZP) and entrapment efficiency (%EE) of nanosuspensions. The physical characteristics of nanosuspensions piroxicam were evaluated by using particle size analyzer and a UV–visible spectrophotometer. The results of optimized formulations showed that the interaction among Chitosan, PVP K30 and STPP was the most dominant factor to influence particle size distribution, zeta potential, polydispersity index and % entrapment efficiency. The nanoprecipitation method was used to prepare biodegradable nanosuspensions of reproducible sizes in the range (100-300 nm) with spherical shape by addressing the effects of processing parameters. Based on superimpose counterplot, it is obtained the optimum area with proportion of (X1):27,5-43,4%; (X2): 20,9-46,9%; (X3): 30,6-40,2%. The use of an experiments design allows us to study the influence of different factors of formulation and manufacturing process on the formulation process, and to reduce the number of experiments. © 2016, International Journal of Pharmaceutical and Clinical Research. |
