Application Nanoemulsion of Beta Carotene in the Mucoadhesive Patch
Penulis/Author
Tanggal/Date
9 2020
Abstrak/Abstract
Beta carotene applied to the mucoadhesive gingiva patch was not significantly reduced the micronucleus as the negative effects of panoramic radiographic exposure on patients dental examination. Its solubility in the patch matrix was very low. Development of beta carotene nanoemulsion using combination of Rice Bran Oil (8%), Tween 80 (85%) and PEG 400 (7%) is expected to increase the solubility that dispersed into the mucoadhesive patch preparation. Beta carotene nanoemulsion mucoadhesive patches produced has a weight 91.0 ?0.2 mg; thickness 0.18 ?0.01 mm; folding endurance more than 300 times; maximum swelling 120.07 ?5.28 % at 10 minutes; and patch surfacepH 6. The amount of beta carotene that dispersed into the patch matrix increased up to 14.39 ?0.52 ?g/4 cm2. The patch stuck to the rabbit palatal mucosa in 44.64?4.24 minutes and its released beta carotene across cellophane membranes by 19.7 ± 1.74 % in8hours. SNEDDS formulations could increase the amount of beta carotene that dispersed into the mucoadhesive matrix carotene nanoemulsion patch and released beta carotene across the cellophane membrane following the Korsmeyer-Peppas kinetics and the mechanism of Fickian release.
Rumpun Ilmu
Farmasetika dan Teknologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
54_RJPT_13_8_2020-1 harni.pdf
[PAK] Full Dokumen
2
L1-Ronny Martien-2020 Beta caroten.pdf
3
Application Nanoemulsion of Beta Carotene in the Mucoadhesive Patch.pdf
[PAK] Cek Similarity
4
Application Nanoemulsion of Beta Carotene in the Mucoadhesive Patch.pdf
