Antimicrobial effects of Indonesian Medicinal Plants Extracts on Planktonic and Biofilm Growth of Pseudomonas aeruginosa and Staphylococcus aureus
Penulis/Author
Dr. Sylvia Utami Tunjung Pratiwi, S.Si., M.Si. (1); Prof. Dr.rer.nat. apt. Triana Hertiani, S.Si., M.Si. (3)
Tanggal/Date
2015
Kata Kunci/Keyword
Abstrak/Abstract
Nowadays it is known that resistance to antibiotics is often caused by biofilm formation of the microbial pathogen. The aim of this study is to evaluate the activity of Indonesian medicinal plants extracts on planktonic growth and biofilm of two bacteria species. Fifty four (54) ethanol extracts were obtained from a variety of known Indonesian medicinal plants. The growth inhibitory concentration (MIC), effects on biofilm formation and biofilm breakdown, and biofilm architecture in the absence and presence of the extracts by confocal laser-scanning microscopy were performed with Pseudomonas aeruginosa PAO1 and Staphylococcus aureus Cowan I. The extracts showed an inhibitory effect on planktonic growth of these bacteria and also on their biofilm formation. At a concentration as low as 0.12 mg/mL, biofilm formation of P. aeruginosa PAO1 and S. aureus Cowan I is inhibited by 5 plant ethanol extracts : Kaempferia rotunda L., Caesalpinia sappan L., Cinnamomum burmanii Nees ex Bl., C. sintoc L., and Nymphaea nouchali Burm.f. Limited bacteriostatic activity was evident. The results obtained clearly indicate the extracts obtained are interesting sources of putative antibiofilm agents. This research can contribute to the development of new strategies to prevent and treat biofilm infections.
Rumpun Ilmu
Biologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
4021-18206-1-PB.pdf
2
ANTIMICROBIAL EFFECTS OF INDONESIAN MEDICINAL PLANTS EXTRACTS ON PLANKTONIC AND BIOFILM GROWTH OF PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS.pdf
