Antihyperuricemic activity of the Kepel [Stelechocarpus burahol (Bl.) Hook. F. & Th.] leaves extract and xanthine oxidase inhibitory study
Penulis/Author
Dr. Purwantiningsih, S.Si., M.Si., Apt. (1); apt. Arief Rahman Hakim, S.Si., M.Si. (2); Dr. apt. Indah Purwantini, S.Si., M.Si. (3)
Tanggal/Date
2010
Kata Kunci/Keyword
Abstrak/Abstract
Kepel or Stelechocarpus burahol ( Bl.) Hook. F & Th. is one of the original plants from Indonesia and has been traditionally used for gout by
the Indonesian communities. Kepel has synonyms name as Burahol and Turalak, and some studies showed that the extract and isolated
flavonoid from Kepel leaves have antihyperuricemic and antioxidant activity. The aim of this research is to evaluate the antihyperuricemic
potency of the ethanol and hexane extract of Kepel leaves as compared to allopurinol. The experiment was divided into two parts, invivo
and invitro
studies. For invivo
study, sixty five rats were used in the study and the rats were divided into 13 groups (n=5 per group). The
groups were assigned as follows and the test substances were given orally. Group 1: rats were given 10 ml/kg b.w. of 0.5% CMC?Na;
Groups 2?5: rats were given 4.5 to 36 mg/kg b.w. of allopurinol; Groups 6?9: rats were given ethanol extract of Kepel leaves (50 to 400
mg/kg b.w.); and Groups 10?16: rats were given hexane extract of Kepel leaves (50 to 400 mg/kg b.w.). The blood of the test animals were
taken through the eye vein on days 15, 17 and 19 post?treatment. Serum uric acid levels was determined by using TBHBA [2,4,6tribromo3hydroxy
benzoic acid] method and the percentage of the degradation was calculated. Inhibitory potency of the ethanol extract to the
xanthine oxidase, was done by using procedure Fried & Fried (1993) and compared to allopurinol. Based on this study, it could be
concluded that the ethanol and hexane leave extracts of Kepel possess significant antihyperuricemic potency in rat. The antihyperuricemic
activity of the ethanol (60.86 to 78.33 %) and hexane extracts (78.23 to 88.52 %) are almost equivalent to that of the allopurinol (50.82 to
91.16%). While invitro
study showed that the ethanol extract has the inhibitory activity lower than allopurinol.
Rumpun Ilmu
Farmakologi dan Farmasi Klinik
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
3_1_ Antihyperuricemic Activity ___ International Journal 2010.pdf
[PAK] Full Dokumen
2
Antihyperuricemic Activity of the Kepel Stelechocarpus burahol (Bl_) Hook_ F_ & Th_] Leaves Extract and Xanthine Oxidase Inhibitory Study.pdf
