| Abstrak/Abstract |
Seledri (Apium graviolens L.), kumis kucing (Orthosiphon stamineus Benth.), and mengkudu (Morinda
citrifolia L.) have been used to treat hypertension diseases in Indonesia. Previous researches have been done
to determine antihypertensive activity of extracts of the sample in single extract. However, there are limited
studies on effect of the extracts on a combination of three samples. This research was therefore aimed to study the
effect of the combination on lowering blood tension on normotensive and spontaneously hypertensive rats. Non
Invasive Blood Pressure technique equipped with Non Invasive Blood Pressure System (CODA®) was used to
measure effect of extracts on antihypertensive activity. Sprague Dawley rats were divided into 2 groups
(normotensive and spontaneously hypertensive rats using fenilefrin) and treated with combination extracts in
doses of 20.25 and 40.5 mg/kg BW of rats. The result showed that the combined extracts can decrease in blood
pressure of both two of the groups. Normotensive group of the rats treated at doses of 20,25 and 40,5 mg/kg BW of
rats had lower persentase of systolic blood pressure as much as 7,1 ± 1,8 % and 10,2 ± 2,6 %, whilst percentage of
diastolic blood pressure had lower percentage as much as 13,8 ± 3,2 % and 12,3 ± 3,1 %, respectively.
Furthermore, spontaneously hypertensive rats treated at doses of 20,25 and 40,5 mg/kg BW of rats also
showed lower systolic blood pressure as much as 16,10 ± 0,90 % and 15,84 ± 1,55 % and diastolic blood
pressure as much as 19,48 ± 1,03 % and 17,77 ± 1,34 %. These results suggest that administration of
combination of three extracts exhibited antihypertensive in both of the rat groups. |
