Karya
Judul/Title Antihypertensive effect of functional rice analogue containing corn, mocaf, pigoen pea and seaweed on rats
Penulis/Author apt. Rumiyati, S.Si., M.Si., Ph.D. (1) ; Prof. Dr. apt. Agung Endro Nugroho, S.Si., M.Si. (2); Prof. Dr. Yekti Asih Purwestri, S.Si., M.Si. (3); Prof. Dr. Yudi Pranoto, S.T.P., M.P. (4); Satrijo Saloko (5); Sri Widyastuti (6)
Tanggal/Date 22 2023
Kata Kunci/Keyword
Abstrak/Abstract The ingredients of rice analogue used in this research are corn (Zea mays), lebui or pigeon pea (Cajanus cajan (L.) Millsp.), mocaf (fermented cassava) and seaweed (Euchema cottonii) which was formulated in different compositions of amylose and amylopectin namely formula F30 (contain 30% amylose) and F31 (contain 31% amylose). Nutritive and bioactive compounds in the ingredients are supposed to have a role in the activity of blood pressure reduction. Therefore, it is necessary to conduct research to determine whether the rice analogue in the two formulas can reduce the blood pressure in Wistar rats, both in normotensive and hypertensive conditions. Evaluation of the nutritive and their bioactive contents in the raw materials of the rice analogue is also be done. Rice analogue was prepared with a composition as the formula, followed by chemical content analysis and in vivo experiment. In the in vivo experiment, rats were divided into two major groups. One was the normotensive group, and the other was the hypertensive group (induced by dexamethasone). Blood pressure measurements were carried out using the CODA® Non-Invasive Blood Pressure tool. Blood pressure measurement data were analyzed using the Wilcoxon Signed-Rank and the Kruskall Wallis Test statistical tests, followed by the Mann Whitney Test using 95% confidence level with the calculation of the percentage change in blood pressure. The results showed that changes in blood pressure, both in normotensive and hypertensive conditions treated with the rice analogue diet, did not differ significantly (p > 0.05) when compared to standard feeding. The percentage changes in systolic blood pressure (SBP) in the normotensive group treated F30 and F31 rice analogue were -0.29±1.5% and 1.14±1.8%, respectively, while for diastolic blood pressure (DBP) were -0.43±1.8% and 8.3±8.0%. Whereas in the hypertensive group, the percentage changes in SBP in the group treated F30 and F31 rice analogue were 3±0.09% and 6±0.08%, respectively, while for DBP were -2±0.15% and 6±0.15%. Percentage change in blood pressure that is negative indicates a decrease in blood pressure, while a positive value indicates a rise in blood pressure. Nutritive and bioactive compounds in the rice analogue might be have a role in regulation of blood pressure. The amount of the ingredients in the rice analogue of F30 and F31 for an optimal antihypertensive is needed to be evaluated.
Rumpun Ilmu Analisis Farmasi dan Kimia Medisinal
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1FR-2022-067 Acceptance Letter.pdfBukti Accepted
2Rumiyati-FR-2022-067-.pdf[PAK] Full Dokumen
3[Manuscript Submission_ Rumiyati et al] - rumiyaris@ugm_ac_id - Universitas Gadjah Mada Mail.pdfBukti Submitted
4Gab bukti galley proof.pdf[PAK] Bukti Korespondensi Penulis
5_6__fr-2022-067_rumiyati.pdfBukti Published
6Email-bukti published.pdf[PAK] Bukti Korespondensi Penulis
7Antihypertensive effect of functional rice analogue containing corn, mocaf,.pdf[PAK] Full Dokumen
8Bukti Korespondensi Gabungan lengkap-Rumiyati-Paper Antihipertensiv__.pdf[PAK] Bukti Korespondensi Penulis
9Ithenticate chek-Antihypertensive effect of functional rice analogue containing corn, mocaf,-1[1].pdf[PAK] Cek Similarity