Karya
Judul/Title #Antihypercholesterol activity of Costus speciosus water extract
Penulis/Author HARI SUSANTI (1) ; Prof. Dr. apt. Subagus Wahyuono, M.Sc. (2); Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (3); Prof. Dr. apt. Ratna Asmah Susidarti, MS. (4)
Tanggal/Date 2018
Kata Kunci/Keyword
Abstrak/Abstract Introduction: Hypercholesterolemia is one of the causes of cardiovascular disease. Costus speciosus (CS) is known empirically as an antihypercholesterol remedy. Material and Method: This study was conducted to determine the effect of water extract of CS on cholesterol blood serum level of rat induced-propylthiouracil (PTU). The antihypercholesterol activity performed on male Wistar rats which induced 0.01% PTU (mixed in drinking water, 14 day-induction) was followed by the administration of CS for 14 days. The animals were randomly divided into seven groups: Solvent control (carboxylmethylcellulose 0.5% w/v in water), positive control (simvastatin at dose 7.2 mg/kg BW), negative control (water), CS extract 50, 100, and 200 mg/kg, and normal control. The cholesterol levels were measured at day 0th, 14th, and 28th. Result and Conclusion: Results showed that administration of CS extract 200 mg/kg can reduce the total serum cholesterol equal to simvastatin 7.2 mg/kg.
Rumpun Ilmu Farmakologi dan Farmasi Klinik
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
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