| Abstrak/Abstract |
Biofilm-related infections are challenging to control and treat because of the widespread presence of multidrug-resistant microbes. Biofilm, natural matrix assemblage of microbial aggregates, has expanded intricate and manifold resistance mechanisms to many currently used antibiotics, causing an extensive problem, particularly for human -health issues, such as clinically chronic infectious diseases. Thus, to search forthe discovery and development of new
and more effective antibiotics remain urgent. As the marine environment is considered a propitious reservoir of new biologically active molecules with potential pharmacological properties, marine natural products, particularly those of microbe origin, have become a promising source of antibiofilm agents. Marine microbes remain an untapped source of secondary metabolites with antimicrobial activity. Moreover, marine natural productsas the 42
result of self-defense and harsh conditions adaptation to the marine environment have a wide variety of chemistry, including peptides and polyketides, which have been found predominantly in microbes. These molecules can be exploited to cater provide novel and unique structures for developing alternative antibiotics as effective antibiofilm agents. This review focuses on the possible antibiofilm mechanism of these marine microbial molecules
against biofilm-forming pathogens. An overview of the concept of biofilm development, its recalcitrance mode of action, antibiofilm agents’ strategies, and their assessments is presented. Some selected peptides and polyketides from marine microbes reported between 2016 and
2023 are revisited, but with moderate and considerable antibiofilm activity. Moreover, their antibiofilm mechanisms, such as adhesion modulation/inhibition targeting biofilm-forming pathogens, quorum sensing intervention and inhibition, and extracellular polymeric substance
disruption, are highlighted herein.
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