Karya
Judul/Title Antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide against Candida albicans
Penulis/Author Prof. dr. Titik Nuryastuti, M.Si., Ph.D., Sp.MK(K). (1) ; Setiawati (2); Prof. dr. Ngatidjan, M.Sc.Sp.FK(K) (3); Prof. Dr. Mustofa, Apt., M.Kes. (4); Prof. Drs. Jumina, Ph.D. (5); Dhina Fitriastuti (6); Dr. Muhammad Idham Darussalam Mardjan S.Si., M.Sc. (7)
Tanggal/Date 2018
Kata Kunci/Keyword
Abstrak/Abstract The therapy for invasive candidiasis related to biofilms infection remains a difficult medical problem. To overcome this problem, efforts have been made to search for novel antibiofilm agents from various sources. This study investigated the in vitro antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide (FEN) against Candida albicans. The minimum biofilm inhibitory concentration (MBIC) and minimum biofilm reduction concentration (MBRC) were determined using the MTT (3-(4-5-dimethylthiazol-2-yl)2,5-dyphenyl tetrazolium bromide) reduction assay. Biofilms on surfaces were visualized using scanning electron microscopy (SEM). This new compound inhibited the growth of C. albicans biofilms by 80 % with an MBIC80 range from 0.5–2.0 ?g/mL. The ability of FEN to reduce 50 % of a preformed biofilm was demonstrated by defining a MBRC50 range from 6.25–-12.5 ?g/mL. To reduce 80 % of a preformed biofilm required higher concentrations > 200 ?g/mL. In addition, SEM images showed disruption of C. albicans biofilms matrix exposed to FEN. These results indicated that (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide has the potential to be developed as a new antibiofilm agent against C. albicans.
Rumpun Ilmu Kimia
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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