| Abstrak/Abstract |
Biomedical scaffolds are vital in regenerative medicine, offering a three-dimensional structure that mimics the
extracellular matrix and support cell adhesion, migration, and differentiation. These scaffolds create a conducive
microenvironment for tissue growth and repair, accelerating healing and restoring function. Despite significant
progress in scaffold technology, challenges such as infection, peri-implantitis, and adverse immune reactions
continue to hinder their clinical success. Furthermore, with the rising threat of infections exacerbated by climate
change and antibiotic resistance, there is an urgent need for scaffolds with built-in antimicrobial properties.
There are several strategies to achieve the properties, such as surface functionalization with biomolecules or
structural modifications, which can effectively prevent bacterial adhesion and biofilm formation on scaffold
surfaces. This approach not only enhances the biocompatibility of scaffolds but also reduces the risk of infection-
related complications, making them safer and more effective for clinical applications. This study aims to address
these concerns by providing a comprehensive, state-of-the-art review on the development of biomedical scaffolds
with antimicrobial features, focusing on innovative, adaptable, and resilient technologies that enhance the
success and safety of scaffold-based therapies. |
