Karya
Judul/Title Antibacterial and Anti-biofilm of Secondary Metabolites from Sansevieria trifasciata Leaves Against Pseudomonas aeruginosa
Penulis/Author WHIKA FEBRIA D. (1); Prof. Dr. Laurentius Hartanto Nugroho, M.Agr. (2) ; Prof. Dr. Endah Retnaningrum, S.Si., M.Eng. (3); Prof. Dr. Yekti Asih Purwestri, S.Si., M.Si. (4)
Tanggal/Date 22 2022
Kata Kunci/Keyword
Abstrak/Abstract Sansevieria trifasciata is a herbaceous plant frequently used as a traditional medicine with antibacterial potency against Pseudomonas aeruginosa. P. aeruginosa is a known bacterial pathogen that often becomes resistant due to its ability to form biofilms. This study aimed to investigate the potential antibacterial and anti-biofilm activity fraction of S. trifasciata ethanolic extract against P. aeruginosa. Bacterial cell damage with a potential fraction of S. trifasciata ethanolic extract treatment was observed by SEM (Scanning Electron Microscopy). Anti-biofilm assay applied Microtiter plate 96 wells with crystal violet stain. The MIC (Minimum Inhibitory Concentration) results showed that the potential fraction of S. trifasciata ethanolic extract was able to inhibit bacterial growth at a concentration of 4 mg/mL. On this concentration, the potential fraction of S. trifasciata ethanolic extract could inhibit the biofilm by 60%. Identification of compounds by Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that Neophytadiene was found to be the main active component. These compounds could act as potential therapeutic agents to prevent bacterial biofilms and virulence-related infectious diseases.
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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