| Abstrak/Abstract |
Background: Upper respiratory diseases are our interest as the prevalence is high worldwide and interferes with the quality of life. The pathophysiology of the diseases involves inflammatory reactions, both immunological and non-immunological inflammation. Objective: This study aimed to evaluate the activity of an Indonesian polyherbal product that combines the extracts of Curcuma zanthorrhiza rhizome and Vitex trifolia leaves, as main ingredients, with Zingiber officinale rhizome, Citrus bioflavonoid complex, and Echinacea purpurea herb, as an anti-inflammatory in respiratory disorders. Methods: The effects of the polyherbal product at different doses (167.5, 335, and 670 mg/kg, p.o) on the right hind paw edema were measured by plethysmometer after induction by sub plantar injection of either histamine (100 µl, 2%) or carrageenan (100 µl, 0.1%), to represent two types of inflammation. Rat paw edema volume as baseline (Vo) was measured at 30 min before oral administration of the polyherbal and every 30 min for 0–6 h after injection of histamine or carrageenan (Vt). Anti-inflammatory activity was calculated as the percent inhibition of paw edema relative to the negative control, CMC-Na. Results: The polyherbal formula significantly decreased paw edema compared with the negative control (P < 0.05). Inflammatory inhibition rates of 167.5, 335, and 670 mg/kg doses were 25.19%, 32.77%, and 47.03%, respectively, in histamine-induced edema, and 20.12%, 56.62%, and 68.87%, respectively, in carrageenan-induced edema. Conclusion: The anti-inflammatory properties of a polyherbal containing C. zanthorriza and V. trifolia as the main ingredients showed a dose-dependent manner. The other herbal components i.e. Z. officinale rhizome, Citrus bioflavonoid complex, and E. purpurea herb may contribute to overall anti-inflammatory activity. |
