Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia
Penulis/Author
David Randel Christanto (1); Johanes C. Mose (2); Tetty Yuniarti (3); Muhammad Begawan Bestari (4); Prima Nanda Fauziah (5); Prof. Dr. Yekti Asih Purwestri, S.Si., M.Si. (6); Jefferson N. Munthe (7)
Tanggal/Date
1 2021
Kata Kunci/Keyword
Abstrak/Abstract
Preeclampsia is a multisystem disorder of pregnancy that contributes to
morbidity and mortality worldwide. Soluble FMS-like tyrosine kinase-1 (sFlt-1) is considered as an etiologic factor of endothelial damage in preeclampsia. Imbalance of sFlt-1 and PlGF could cause failure in trophoblastic invasion and physiological remodeling of spiral artery, and ultimately placental hypoxia. This study aimed to observe anti-angiogenic properties of black rice bran on preeclampsia through measurement of sFlt-1 and PIGF. Serum was collected from pregnant women at 28-34 weeks of gestational age with preeclampsia, and normal preeclampsia as control. Level sflt-1 and PGIF was quantified with enzyme linked immunosorbent assay (ELISA). Absorbance was read at 450 nm wavelength. Extract of black rice bran has anti-angiogenic properties by significantly decreasing sFlt-1 as well as increasing PIGF in preeclampsia-induced HUVEC. This makes black rice bran a promising agent which can be further used in preeclampsia treatment.
Rumpun Ilmu
Biologi (dan Bioteknologi Umum)
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
2021_Yekti Asih P_Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L_)_Sys Rev Pharm.pdf
[PAK] Full Dokumen
2
Turnitin22%_Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L_ ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase.pdf
