ADVERSE DRUG REACTIONS OF ANTI -TUBERCULOSIS DRUGS AMONG TUBERCULOSIS PATIENTS IN YOGYAKARTA
Penulis/Author
Prof. Dr. apt. Djoko Wahyono, SU. (1); apt. Woro Harjaningsih, S.Si., Sp.FRS. (2); apt. Fivy Kurniawati, S.Farm, M.Sc. (3); Dr. apt. Fita Rahmawati, Sp.FRS. (4); Dr. apt. Nanang Munif Yasin, S.Si., M.Pharm. (5)
Tanggal/Date
2015
Kata Kunci/Keyword
Abstrak/Abstract
The World Health Organization (WHO) has designated Indonesia as a
"high burden country" for tuberculosis. The treatment regime of
tuberculosis (TB) needs multiple-drug therapy that increases risk of
adverse drug reaction. This study aimed to explore and to observe
adverse reactions occurrence of anti-tuberculosis drugs among
tuberculosis patients and to evaluate clinical outcome after treatment.
An observational cross-sectional study was used in this study. Patients
enrolled this study were patients with tuberculosis medication at the
Primary Health Care in Yogyakarta, Indonesia. The number of those the
study’s setting was 24 Primary Health Care spread in several districts
and municipal in Province of Yogyakarta meanwhile the number of the
patients was 375 who fulfilled inclusion criteria. Data of the study was
descriptively analyzed. The result of this study found that the majority
of the patients were (227 patients or 60, 5%) whereas 181 patients or
48, 2% had age between 20-39 years old. The study also showed 171
patients or 45, 6% suffered from adverse drug reactions during
medication. The most case of adverse drug reactions was skin and
gastrointestinal reactions. The sum of the patients who suffered from
skin reaction was 63 patients (16, 8%) while 63 patients (16, 8%)
experienced gastrointestinal reaction. The clinical outcome of the
treatment including change into negative sputum smear after two
months treatment in 218 patients (58, 1%) and increase of body weight
in 252 patients (67, 2 %).
