Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review
Penulis/Author
dr. He Yeon Asva Nafaisa, M.Sc., Sp.D.V. (1); dr. Fajar Waskito, Sp.KK(K) M.Kes. (2); Dr.rer.nat. Ronny Martien, M.Si. (3); Prof. Dr. Med. dr. Retno Danarti, Sp.KK(K). (4)
Tanggal/Date
30 2024
Kata Kunci/Keyword
Abstrak/Abstract
Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids.
Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier.
Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.
