| Abstrak/Abstract |
The bark of Faloak (Sterculia quadri????ida R. Br., Malvaceae) is used for tradi- tional medicine in Indonesia. This study aims to examine the level of toxi- city of the Faloak bark standardized ethanolic extract. The barks were col- lected from East Nusa Tenggara, Indonesia. TLC pro????ile was determined by TLC-densitometry, total phenolic and ????lavonoid content were determined in ethanolic extract from bark of faloak (S.quadri????ida) by UV-V is method. The acute toxicity was performed according to the TD420 method by OECD (2001) on Wistar rats. The animals were grouped into control and treatment groups (2000 mg/kg body weight). All animals were evaluated for possible toxicity signs by measuring body weight, food and water consumption, and histopathological observation. The result of mean concentration of total phe- nolic content was found to be 17,69±2,01 (%GAE) and concentration of total ????lavonoid content was found to be 8,56 ± 0,02 (%NE). The results showed that no mortality occurs after 14 days of treatment. In general, no signi????icant changes in animal behavior, body weight, food and water consumption com- pared to the control group. Histological observation found no sign of toxic- ity on vital organs. LD50 values obtained from the acute toxicity test results for Faloak ethanol extract (Sterculia quadri????ida R. Bark) are higher than 2,000 mg/kg BW and categorized as having a low level of toxicity |
