| Abstrak/Abstract |
Active matrix metalloproteinase-8 (aMMP-8) is a promising biomarker candidate for the
modern periodontal and peri-implant disease diagnostics utilizing the chairside/point-of-care oral
fluid technologies. These rapid biomarker analysis technologies utilize gingival crevicular fluid
(GCF), peri-implant sulcular fluid (PISF), or mouth rinse as the oral fluid matrices that can be
collected patient-friendly and non-invasively without causing bacteremia. aMMP-8, but not total
or latent proMMP-8, has been shown to be a relevant biomarker to be implemented to the latest
2017 classification system of periodontitis and peri-implantitis. Thus, aMMP-8 point-of-care-testing
(POCT)—but not total or latent proMMP-8—can be conveniently used as an adjunctive and preventive
diagnostic tool to identify and screen the developing and ongoing periodontal and peri-implant
breakdown and disease as well as predict its episodic progression. Similarly, aMMP-8 POCT provides
an important tool to monitor the treatment effect of these diseases, but also other diseases such as
head and neck cancer, where it can identify and predict the rapid tissue destructive oral side-effects
during and after the radiotherapy. Additionally, recent studies support aMMP-8 POCT benefitting
the identification of periodontitis and diabetes as the escalating risk diseases for COVID-19 infection.
Overall, aMMP-8 POCT has launched a new clinical field in oral medicine and dentistry, i.e., oral
clinical chemistry. |
