| Penulis/Author |
Indri Hapsari (1); Prof. Dr. Marchaban, DESS. Apt. (2); Prof. Dr. Chairun Wiedyaningsih, M.Kes., M. App.Sc., .Apt. (3); Prof. Dr. Susi Ari Kristina, S.Farm., M.Kes., Apt. (4) |
| Abstrak/Abstract |
Extemporaneous compounding is a technique to mix, combine or change drugs to produce drugs adjusted to the patients’ conditions or special needs. Dosage of extemporaneouscompounding can be in form of oral and topical dosages. One of the topical dosages is semi-solid. Dosage form changes from its initial (previous) forms by forming other dosages can cause stability changes of the drug. This research aims to determine how the physical quality of semi-solid dosage made at the primary health care canters (Puskesmas).This research was conducted through an observation on extemporaneous compounding process at the health centers, then the researchers tested the physical quality of semi-solidextemporaneous compounding obtained from observations at four different primary health care canters. A
physical evaluation of the semi-solid compounding was carried out starting from day 0 (Week I) up to the 28th day (Week V) including homogeneity, organoleptic, Scanning Electron Microscope (SEM), pH, viscosity, adhesion, dispersion and yield tests. Based on the results of the physical evaluation, it showed that semi-solid extemporaneous compounding made by
Puskesmas Dwas relatively more stable than others where the dosage remained homogeneous until the 14th day (Week III). Organoleptically, the odour occurred on the 21st day (Week IV) , based on SEM test results there was no separation of the prescribed drug, a stable pH during storage with a pH value of 6, had a viscosity value of 5845.60 cps, spreadability of 36.40 cm2 and adhesion of 0.51 seconds, although there was a weakness in the yield value of 72.90%, where the yield was the lowest among the others.This research showed that the best physical quality of semi-solid extemporaneous compounding made by Puskesmas Dis the best among others, because it used drugs having the same dosage form in the form of cream dosage and the compounding process was done using mortar and stamper |
