Bioactivities of A Major Compound from Arthrinium rasikravindrae An Endophytic Fungus of Coleus amboinicus Lour.
Penulis/Author
Prof. Dr. Puji Astuti, S.Si., M.Sc., Apt. (1); Dwi Koko Pratoko (2); Rollando (3); Giri Wisnu Nugroho (4); Prof. Dr. apt. Subagus Wahyuono, M.Sc. (5); Prof. Dr.rer.nat. apt. Triana Hertiani, S.Si., M.Si. (6); Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (7)
Tanggal/Date
29 2021
Kata Kunci/Keyword
Abstrak/Abstract
Many studies reported the ability of endophytic fungi to produce various bioactive compounds having therapeutic values. An endophytic fungus identified as Arthrinium rasikravindrae was isolated from the stem of Coleus amboinicus Lour. This study examined cytotoxic and antimicrobial activities of a major compound isolated from ethyl acetate extract of the fungus fermentation broth. Cytotoxic activities were conducted using MTT assay against T47D, MCF-7, WiDr, 3T3, and Vero cells. IC50 values against Staphylococcus aureus and Escherichia coli were used as the parameters for determining antimicrobial activities. The isolated compound appeared as a single peak in HPLC chromatogram (98.55 %), displayed the highest cytotoxic activity on WiDr cells (IC50 35.03 ± 2.08 ?g/mL) and antimicrobial activities against S. aureus (IC50 232.10 ± 1.20 ?g/
mL) and E. coli (243.59 ± 1.32 ?g/mL). Analysis of the UV spectrum and TLC data generated by various detection reagents revealed that the compound was predicted as an N-containing substance having conjugated double bonds.
Rumpun Ilmu
Biologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
28-Astuti et al 2021 Fabad.pdf
[PAK] Full Dokumen
2
dokumen pendukung insentif publikasi karya ilmiah Mei 2021.pdf
3
Bioactivities of A Major Compound from Arthrinium rasikravindrae An Endophytic Fungus of Coleus amboinicus Lour_.pdf
[PAK] Cek Similarity
4
28-Astuti et al 2021-Fabad-proof of correspondence-revisi.pdf
[PAK] Bukti Korespondensi Penulis
5
PEER REVIEW_PUJI ASTUTI T1_.pdf
[PAK] Peer Review
6
Bioactivities of A Major Compound from Arthrinium rasikravindrae An Endophytic Fungus of Coleus amboinicus Lour.pdf
