| Abstrak/Abstract |
UltravioletA (UVA) rays with an intensity of 95?n induce skin cancer due to the
activation of reactive oxygen species (ROS). The 3,4-dimethoxychalcone (3,4‑DMC)
chalcone derivative has a wide wavelength, antioxidant activity, presumed has activity
as sunscreen (UVA rays). Topical delivery of water‑insoluble 3,4‑DMC with log P 3.84
required capable, cream formulation was chosen because it was suitable for application
this chemical sunscreen. This study aims to obtain the optimal formulation of 3,4‑DMC
in a sunscreen cream dosage form as a UVA‑protection factor (UVA‑PF). This study
involves experimental design. The cream 3,4‑DMC was evaluated physically for 4 weeks
by measuring pH, viscosity, spreadability, adhesion, centrifugation, freeze–thaw,
photostability, UVA‑PF used TranporeTM tape, and skin irritation test on animals. The
result obtained was evaluated statistically using ANOVA (SPSS version 24). The ratio
UVA/UVB value of 3,4 DMC sunscreen cream having 5 stars (*****) for all concentrations,
shows the product in this study can be used as an anti-UVA agent in sunscreen cream
cosmetic products. The stability of the cream has pH 4.0–4.2; spreadability 5–6 cm;
viscosity 4.470–5.763; and adhesion <1 s. Freeze‑thaw and centrifugation were known
did not affect the stability due to the absence of separation. There was no wavelength
shift in the photostability test and no skin irritation due to in vivo examination using
New Zealand rabbits. The 3,4‑DMC as a new agent in conventional sunscreen cream
dosage form has good properties as a protection against UVA rays.
|
